How does t2 Mr work?

T1 and t2 in MRI pdf

Original article: Wagner M, Helfrich M, Volz S, Magerkurth J, Blasel S, Porto L, et al. Quantitative T2, T2*, and T2′ MR imaging in patients with ischemic leukoaraiosis might detect microstructural changes and cortical hypoxia. Neuroradiology. 2015 Jul 31. [Epub ahead of print].

Abstract: Prospective controlled study assessing patients with ischemic leukoaraiosis compared to healthy controls using high-resolution T2, T2* and T2′ mapping sequences; associated with cerebral perfusion analysis using PASL and segmentation of SG and SB for quantitative assessment between groups.

Blood-water transverse relaxation time is highly dependent on blood oxygenation. The result of differences in magnetic susceptibility between blood vessels and adjacent brain parenchyma results in reduced T2* transverse relaxation time effect. However, T2* increases in the thalami and cerebral cortex with age due to edema or gliosis. Therefore, it is proposed to assess the T2′ relaxation time calculated by the following formula 1/T2′ = 1/T2* – 1/T2. T2′ helps to obtain information about deoxyHb concentration.

Resonancia t1 y t2 diferencias

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T1 and t2 column

Several methods have been developed to achieve maximum accuracy with minimum time consumption. Typically 15 to 30 magnetization measurements are carried out on the sample with different time delays; TI in recovery-inversion experiments and TR in partial saturation experiments. Based on these results a T1 value is calculated with error limits generally less than 5%.

Calculations based on fast pulse sequences (i.e., not “clean” sequences other than IR or SE) lead to rough estimates of T1, T2, T2* (and proton density) values. They might be “reproducible” when repeated, but the use of relaxation time values acquired with such pulse sequences is not advisable for scientific or clinical comparisons.

Relaxation time values and proton density calculation. The current method used to obtain a T1 image, i.e., an image whose components represent pure T1 values, is based on a mathematical manipulation of images with different T1 influence obtained separately. Measurements are easier and more accurate at low and medium fields, because T1 values are shorter, ECG triggering is less complicated, and artifacts less pronounced at these fields.


Magnetic resonance imaging (MRI) is a study method to produce detailed images of organs and tissues through a magnetic field and rapidly changing radio waves. The resulting images are then displayed on a computer to determine if a lesion is present and at what level.

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The basis of the imaging is the measurement of the energy released and the time in which they return to their relaxed state once they are no longer stimulated. By means of this radiological study, high quality images of the human body are obtained, allowing precise diagnoses to be made. Thanks to magnetic resonance imaging we have been able to open before us the different sections of tissues, organs and vascular structures.

4. The rate of energy release is determined by the intrinsic relaxation properties of each tissue, characterized by longitudinal relaxation (T1) and transverse relaxation (T2) times.

10. Among those approved for clinical use in MRI, the most widely used contrast agent is a T1-shortening drug called gadopentetate dimeglumine (or Gd-DTPA), because it contains gadolinium, a paramagnetic agent (atoms with unpaired electrons in their outer shells).